Research Scientist Biophysical Characterization

Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and autoimmune diseases. We are driven by one goal: to develop new treatments to improve the standard of care for patients.

Research Scientist Biophysical Characterization

The role

The department of Analytical Development and Quality Control (ADQC) plays a key role in Byondis’ development and manufacturing, as biotechnology-derived medicinal products cannot be designed, improved or used without extensive and accurate analytical measurements. Therefore, we take pride in providing high quality analytical information to ensure the safety and efficacy of our innovative products for patients.

ADQC is responsible for all analytical testing to enable the development, manufacture and use of biotherapeutic products for toxicological assessments and clinical trials. The department develops, qualifies and applies a broad panel of analytical methods to characterize new biological entities such as monoclonal antibodies and antibody drug conjugates.

For this purpose, a range of sophisticated analytical technologies is available, ranging from chromatography, electrophoresis, mass spectrometry, spectroscopy, microbiology to cell-based assays. ADQC comprises a diverse and multidisciplinary team of about 45 people with in-depth knowledge and experience in various analytical areas. We always seek collaboration and are determined to provide answers rather than test results.

The Research Scientist Biophysical Characterization will be part of the Extended Analytical Characterization Team within Analytical Development that is responsible for the in-depth, non-GMP, characterization of all molecules in CMC development at Byondis, meaning proteins (monoclonal antibodies), small molecules (excipients) and the combination of both: antibody-drug conjugates. Activities include: analytical development and execution of biophysical methods, including spectroscopy (e.g. CD, FT-IR, fluorescence), thermal analysis (e.g. DSC) and light scattering (e.g. DLS, mass photometry), for a variety of purposes, including support of process development, comparability studies, qualification of reference materials, etc. Next to that, providing troubleshooting support and addressing scientific questions arising during the early development of Byondis’ therapeutic products make up an integral part of our activities. Lastly, keeping up with developments in the field through surveying literature as well as internal and external interactions, is important.

Core competences:

• Taking ownership of activities with a mindset focused on precision and quality of your own, as well as the team's, work involving data acquisition, adequate data analysis and clear and concise reporting.
• A natural team player with an attitude to collaborate and communicate.
• Being flexible to act in a fast-changing and demanding environment.
• You are result-oriented and use proactivity and creativity as your methodology to find solutions.
• You are self-motivated, which enables you to work with a high degree of independence.

Your profile

Your letter of motivation and CV should show that you have:

• An M.Sc. degree in analytical sciences, (bio)chemistry, etc.;
• Demonstrable and relevant experience in a comparable position and/or work environment;
• Experience with the development and execution of biophysical characterization methods for biopharmaceutical products;
• Up-to-date knowledge on biophysical analytical approaches for protein characterization;
• Excellent command of the English language, both verbally and in writing;
• Willingness to continuously develop and expand your skills, knowledge and expertise and support your direct colleagues in doing the same.

Benefits and well being

Besides a competitive salary, we offer you a dynamic working environment at our state of the art campus in Nijmegen.  Our values as integrity, authenticity, entrepreneurship, quality and trust are very highly regarded. We also offer an excellent pension scheme, 30 days annual holidays based on a fulltime position and we organize several company events throughout the year. 

Join Byondis and create the future you want, today

Applicants must be nationals of a Member State of the European Union or hold a valid work permit for the European Union.

For further information, please contact Francois Hugen, HR Advisor, at tel. +31 (0)24 679 5100 or by email; recruitment@byondis.com. If you are interested in joining Byondis in this challenging position, we welcome your application via the apply button. We'll keep searching until we find the best candidate or please send in your application before